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Gut serotonin staying in the gut, walled off from the brain by the blood-brain barrier

Daylight, brain serotonin, and the gut's separate pool

Feb 26, 2026 | 7 min read

Morning light reaches brain serotonin through the eye. The gut's serotonin does not commute upstairs to become a mood.

#Dopamine #Sleep architecture
A late plate of food landing after the evening insulin window has narrowed

A late meal and the next morning's insulin

Feb 19, 2026 | 7 min read

Eating late lands the meal when insulin sensitivity is already lower, and the next morning still shows it.

#Cortisol
A sleep hypnogram with the largest hormone pulse sitting on slow-wave sleep

Growth hormone waits for deep sleep, not for an early bedtime

Feb 12, 2026 | 7 min read

The big growth-hormone pulse rides slow-wave sleep. Going to bed early does nothing if that deep sleep never arrives.

#Sleep architecture #Cortisol
A hand resting on a forearm, the scale of touch this piece means

Light affection and the oxytocin pulse

Feb 5, 2026 | 7 min read

A hand on an arm can raise oxytocin when the touch is wanted. The pulse is a context signal, not a switch.

#Oxytocin
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2026 - Substrate Notes

Independent notes on human biochemistry. Written for curious readers, not exam panels.

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