Site logo Substrate Notes
  • Home
  • Posts
  • About
  • Tags
  • Archive

All Posts

A nerve axon depending on a sodium gradient to fire

Why nerves misfire when you only drink water

Mar 26, 2026 | 7 min read

A nerve fires on a sodium gradient. Drinking only water during long effort can wash that gradient down.

#Inflammation
Shivering and sympathetic activation in the first minutes of cold

Cold hits the nerves first and the thyroid later

Mar 19, 2026 | 7 min read

The first response to cold is sympathetic. Thyroid hormone turnover changes on a slower clock than shivering.

#Cortisol
Lactate leaving working muscle and being taken up by heart and other muscle

Lactate is a fuel, not the thing that burns

Mar 12, 2026 | 6 min read

Working muscle ships lactate as a fuel other tissues can oxidize. The burn is not lactate acting as a toxin.

#Mitochondria
The hour after orgasm, with prolactin rising as arousal falls

What an orgasm changes in the next hour

Mar 5, 2026 | 7 min read

After orgasm, prolactin often rises and oxytocin can rise with it. The next hour is a hormone shift, not a cure.

#Oxytocin #Dopamine
Next
2026 - Substrate Notes

Independent notes on human biochemistry. Written for curious readers, not exam panels.

Privacy Policy · Terms of Use