The soreness after a long effort is not the same signal as chronic inflammation, and muscle IL-6 is not a fire alarm.
The mid-afternoon slump is circadian and post-meal, with mitochondria supplying ATP at the pace the cell allows.
Dopamine in hard effort is a keep-going signal, not a pleasure spray that arrives when the work is over.
A short night raises the morning cortisol signal and makes the same breakfast harder for insulin to clear.